This study makes key observations that Candida cells ‘mask’ β-1,3-glucan when grown on lactate, demonstrating that metabolic adaptability makes Candida cells an immunological moving target. Lactate signalling regulates fungal β-glucan masking and immune evasion.
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Carbon source-induced reprogramming of the cell wall proteome and secretome modulates the adherence and drug resistance of the fungal pathogen Candida albicans. Host carbon sources modulate cell wall architecture, drug resistance and virulence in a fungal pathogen. This study demonstrates that intact AmBisome vesicles can carry non-elastic gold particle cargoes through the fungal cell wall.Įne, I. The viscoelastic properties of the fungal cell wall allow traffic of AmBisome as intact liposome vesicles. Outer chain N-glycans are required for cell wall integrity and virulence of Candida albicans. Properties and applications of linear polyurethanes in polyurethane elastomers, copolymers and ionomers. Synthesis methods, chemical structures and phase structures of linear polyurethanes. This report utilizes solid-state nuclear magnetic resonance to demonstrate that chitin and α-1,3-glucan in the Aspergillus cell wall forms a hydrophobic scaffold which is surrounded by β-glucans and capped by glycoproteins and α-1,3-glucan. Molecular architecture of fungal cell walls revealed by solid-state NMR. albicans cell wall and includes a menu of icons which can be used to construct other bespoke cell wall models. This publication provides the first to-scale model of the C. Scalar nanostructure of the Candida albicans cell wall a molecular, cellular and ultrastructural analysis and interpretation. Evidence for a transient non-crystalline state of chitin. Chitin biosynthesis by a fungal membrane preparation. Ultrastructural differences between wall apices of growing and non-growing hyphae of Schizophyllum commune. Ultrastructure of chitin in hyphae of Candida albicans and other dimorphic and mycelial fungi. Crosstalk between the calcineurin and cell wall integrity pathways prevents chitin overexpression in Candida albicans. Priming and elongation of chitin chains: implications for chitin synthase mechanism. Modern biophysics redefines our understanding of fungal cell wall structure, complexity, and dynamics. Structural polymorphism of chitin and chitosan in fungal cell walls from solid-state NMR and principal component analysis. Individual chitin synthase enzymes synthesize microfibrils of differing structure at specific locations in the Candida albicans cell wall. Triple helix conformation of β- d-glucan from Ganoderma lucidum and effect of molecular weight on its immunostimulatory activity. Structural insights into recognition of triple-helical β-glucans by an insect fungal receptor. Chitin in Nature and Technology (Springer, 1986). Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts. The structure of cell wall α-glucan from fission yeast. in Oxford Textbook of Medical Mycology Ch. How does a hypha grow? The biophysics of pressurized growth in fungi. Network traits predict ecological strategies in fungi. Imaging of long-distance α-aminoisobutyric acid translocation dynamics during resource capture by Serpula lacrymans. Fungal aquaporins: cellular functions and ecophysiological perspectives.
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This publication explores the biophysical properties of fungal cell wall hydrophobin layers and shows that they have remarkable breathable yet waterproof properties.
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Fungal hydrophobins render stones impermeable for water but keep them permeable for vapor. Hydrophobins: multifunctional biosurfactants for interface engineering. Penetration of hard substrates by a fungus employing enormous turgor pressures. Autophagic fungal cell death is necessary for infection by the rice blast fungus. Veneault-Fourrey, C., Barooah, M., Egan, M., Wakley, G. This report demonstrates that cell wall thickness fluctuates during cell growth and is regulated by a mechanosensitive homeostatic mechanism. Mechanosensation dynamically coordinates polar growth and cell wall assembly to promote cell survival. Cell wall remodeling enzymes modulate fungal cell wall elasticity and osmotic stress resistance. Effects of cell wall deficiency on the synthesis of polysaccharide-degrading exoenzymes: a study on mycelial and wall-less phenotypes of the fz sg os-1 (‘slime’) triple mutant of Neurospora crassa. A genomic approach for the identification and classification of genes involved in cell wall formation and its regulation in Saccharomyces cerevisiae. Origins of variation in the fungal cell surface.